• br STAR Methods br Acknowledgments

  2024-07-12

  

  STAR★Methods Acknowledgments We thank Simcere Pharmaceuticals, Nanjing, China, for providing a rabbit anti-VEGF neutralizing monoclonal antibody. We thank Dr. Schlisio in the Ludwig Institute for Cancer Research, Karolinska Institute, for assistance with hypoxia assay. Y.C.’s laboratory is sup

• One of the specifications of the

  2024-07-12

  

  One of the specifications of the NIA-AA research framework was that it cyp450 inhibitors be applicable in two distinct research contexts—interventional trials and observational research. In many if not most modern AD interventional trials, individuals are selected for inclusion with the aid of bioma

• To date defining the prognostic

  2024-07-12

  

  To date, defining the prognostic impact of molecular drivers of early-stage NSCLC has been challenging due to the relative rarity of these subsets and the redefinition of comparator arms over time as understanding of the molecular drivers of NSCLC evolved. Indeed, use of molecularly heterogeneous co

• br Functional consequences of ADK regulation on astrocyte fu

  2024-07-12

  

  Functional consequences of ADK regulation on astrocyte function As outlined above (see introduction), ADK critically regulates the extracellular adenosine levels in Deferiprone synthesis (Boison, 2006, Etherington et al., 2009). Changes in the levels of adenosine, as a result of the regulation of

• Epithelial mesenchymal transition EMT is the

  2024-07-12

  

  Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical Mycophenolate Mofetil cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and

• In pioneering work from Ikeda

  2024-07-12

  

  In 2006, pioneering work from Ikeda and colleagues showed that GMF localizes to and regulates the Methotrexate synthesis cytoskeleton (see Glossary), and noted its sequence similarity to ADF/cofilin[11]. In 2009, the structure of GMF [6] was solved, revealing it to be a bona fide member of the acti

• Because activation of HT A

  2024-07-11

  

  Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,

• br Methods br Results br Discussion br Acknowledgements

  2024-07-11

  

  Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V

• We conducted the largest drug screen to date in HPV

  2024-07-11

  

  We conducted the largest drug screen to date in HPV-positive cancers and identified Aurora kinase inhibitors as effective and understudied drugs in HNSCC and CESC. These drugs cause apoptosis and cell cycle arrest in vitro and decrease tumor size in vivo. This is the first published study to demonst

• Production of reactive oxygen species ROS during

  2024-07-11

  

  Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the XL184 [26]. Several studies have indicated that the 12/15-LOX is a pro-in

• Recent studies have demonstrated significant cross

  2024-07-11

  

  Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in Cinacalcet HCl excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [31]. We have recently

• Our research is the first to report that administration

  2024-07-11

  

  Our research is the first to report that administration of HMW-HA is an effective strategy to defend against PM2.5-induced disruption of pulmonary epithelial barrier and lung injury, and addresses that HMW-HA restricts PM2.5-induced epithelial apoptosis through reducing oxidative stress and followin

• In our approach using BRET and FRET there is a

  2024-07-11

  

  In our approach using BRET and FRET, there is a substantial increase in BRET and FRET signals between Giα2 or Giα3-YFP and CFP- Gγ2/Rluc-Gγ2 upon apelin-13 activation, indicating that Gαi2, Gαi3 and N-terminus of Gβ1γ2 subunits become closer without subunit dissociation. In contrast, both the FRET a

• In an effort to increase

  2024-07-11

  

  In an effort to increase antioxidant properties of peptides from WP, Le Maux et al. (2016) altered the hydrolysis conditions (pH, enzyme type, reaction time, and temperature). Hydrolysis of WP (81% protein) test samples with papain (EC 3.4.22.2) at a constant pH of 7.0 gave significantly higher ORAC

• br Experimental All reagents were analytical

  2024-07-11

  

  Experimental All reagents were analytical grade and were used without further purification. The morphology was characterized using a field emission scanning electron microscope (Philips XL-30 FESEMFeSEM, ZEISS SUPRA 40VP, Germany). The hydrogel sample used for SEM analysis was freeze dried. All e

15995 records 121/1067 page Previous Next First page 上5页 121122123124125 下5页 Last page