• Breast Cancer Although androgens have been considered to be

  2023-08-14

  

  Breast Cancer: Although androgens have been considered to be a risk factor in prostate cancer they have been recommended to treat breast cancers. Even before the discovery of SERMs and aromatase inhibitors, steroidal androgens such as medroxyprogesterone and fluoxymesterone were used to treat breast

• Treatment of RAW cells with AP exosomes caused an

  2023-08-14

  

  Treatment of RAW264.7 nisin with AP(+)-exosomes caused an increase in their phagocytic activity. In the presence of amastatin, phagocytic activity was not completely suppressed, suggesting that at least two components were responsible for the activity; one of which is aminopeptidase(s). When the ac

• The preferential expression of ALOX B in human

  2023-08-14

  

  The preferential expression of ALOX15B in human macrophages may explain why human genetic studies investigating the association of ALOX15 with cardiovascular disease did not show consistent results. Two rare functional polymorphisms have been characterized in the ALOX15 gene, which leads to increase

• These mutations induce the gene auto activation in of adenoc

  2023-08-14

  

  These mutations induce the gene auto-activation in 10–40% of adenocarcinomas, triggering the EGFR-signaling pathway in the absence of ligand. That leads to an uncontrolled acceleration of cell proliferation, survival and anti-apoptotic signals (Couraud et al., 2012). The frequency of these mutations

• In glaucoma the primary retinal defect appears in the GCL

  2023-08-14

  

  In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor

• There is a growing literature

  2023-08-14

  

  There is a growing literature on ABCA2 expression in human biopsies, where it has been described as a potential biomarker of leukemias. In childhood T-cell acute lymphoblastic leukemia, ABCA2 and ABCA3 were expressed at high levels, which upon treatment with methotrexate, vinblastine and doxorubici

• The importance of insulin in controlling lipolysis and

  2023-08-14

  

  The importance of insulin in controlling lipolysis and fat mass is further emphasized by mouse models with alterations in the insulin signaling pathway of adipocytes. For example, mice with a tamoxifen-inducible knockout of the insulin receptor in mature adipocytes reveal a substantial decrease of a

• br Results br Discussion To achieve quantitative

  2023-08-14

  

  Results Discussion To achieve quantitative understanding of Naringin turnover, we utilize rapidly moving lamellipodial fragments that are geometrically simple, structurally homogeneous, and persistent, and measure relevant rates and concentrations in this system. We find that the lamellipodia

• Introduction Myasthenia gravis MG is an

  2023-08-14

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic Ac-DEVD-AFC receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis of MG. E

• The approach of enzymatically converting

  2023-08-10

  

  The approach of enzymatically converting an analyte and detecting it by the resulting small pH changes near the reduced graphene oxide (rGO) surface has successfully been pursued in case of urea (Piccinini et al., 2017). Furthermore, this work reported that electrostatic layer-by-layer (LbL) assembl

• br Conclusion br Conflicts of interest br Acknowledgements T

  2023-08-10

  

  Conclusion Conflicts of interest Acknowledgements The authors are grateful to the Ministry of Food Processing Industries, Govt of India (V45/MFPI/R&D/2000 Vol.IV) and Department of Biotechnology, New Delhi, Govt. of India (BT/475/NE/TBP/20132), American Bamboo Society and Ned Jaquith Founda

• IRAK inhibitor 1 Finally intracrine androgen synthesis metab

  2023-08-10

  

  Finally, intracrine androgen synthesis/metabolism can be activated thus allowing IRAK inhibitor 1 to bypass the low levels of androgens in the circulation by producing androgens themselves (Cai and Balk, 2011, Rahman et al., 2004). Moreover, changes in AR co-regulators like the overexpression of ste

• Inhibition of autophagy has been shown to

  2023-08-10

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• We found that decreased Ng levels lead to a lower

  2023-08-10

  

  We found that decreased Ng levels lead to a lower threshold for LTD induction at L4–L2/3 synapses. Previous studies in hippocampal slice culture have shown that LTD at individual synapses induces spine elimination at both the targeted synapse and selective neighboring synapses when spines are monito

• Phytoremediation technology is defined as the use of plants

  2023-08-10

  

  Phytoremediation technology is defined as the use of plants to remove contaminants from soils or to render them harmless, and is regarded as a cost-effective, environmental-friendly method for reclaiming soils contaminated by toxic metals (Lasat, 2002, Mahar et al., 2016, Marrugo-Negrete et al., 201

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