• MTX is a major component of the curative treatment

  2020-08-03

  

  MTX is a major component of the curative treatment of childhood ALL, and the extent of accumulation of its active polyglutamates (MTXPG) determines its cytotoxicity and influences treatment response in childhood ALL. GGH converts long-chain MTXPG into shorter-chain MTXPG and ultimately into MTX, whi

• When multiple concurrent users simultaneously make a request

  2020-08-03

  

  When multiple concurrent users simultaneously make a request for GUI initialization, the server side is not able to respond to all users at the same time. Therefore, the “min” column in Fig. 17 gives the time taken for the first user to receive the response and complete the initialization process.

• The first structure of the catalytic

  2020-08-03

  

  The first structure of the catalytic region of human OGT was reported in 2011 (PDB 3PE4; Figure 2a) [28]. This structure, a complex with UDP and a peptide substrate (CKII), contained 4.5 TPRs. The TPRs in this structure partially overlap with the previously crystallized TPR region, and a full-length

• Cigarette smoking plays a chief risk

  2020-08-03

  

  Cigarette smoking plays a chief risk factor in various neurovascular complications [21]. The mechanism of CSE induced neurovascular complications are activates the immune cells like glial cells, dendritic cells, mast cells and so on [22]. In addition, it also alters the cellular metabolic pathways l

• In the last several decades

  2020-08-03

  

  In the last several decades, molecular genetic studies have identified many genes required for different aspects of meiotic recombination using variety of model species 7., 33., 34., 35., 36.. However, few DNA synthesis components associated with meiotic recombination have been described. DNA synthe

• br Introduction DNA ligation is required during

  2020-08-03

  

  Introduction DNA ligation is required during DNA replication and to complete almost all DNA repair events. In human cells, the DNA ligases encoded by three LIG genes are responsible for joining interruptions in the phosphodiester backbone [1]. These enzymes have distinct but overlapping functions

• MEN Montelukast Zafirlukast and Pranlukast antagonized leuko

  2020-08-03

  

  MEN91507, Montelukast, Zafirlukast, and Pranlukast antagonized leukotriene D4-induced bronchoconstriction in guinea-pigs, following both intravenous and oral administration. When administered intravenously, MEN91507 was the most potent amongst the CysLT1 receptor antagonists tested, since the ED50s

• Chronic renal failure caused significant

  2020-08-03

  

  Chronic renal failure caused significant increases in the serum levels of leukotriene B4, and the pro-inflammatory cytokines TNF-α, IL-1β and IL-6 (Fig. 1; p ratio of both neutrophils and lymphocytes was significantly increased in rats with CRF (pNSC697923 receptor tissues, were found to be signific

• br Conclusions br Funding This work was supported by Grant

  2020-07-31

  

  Conclusions Funding This work was supported by Grant 1512-366261/758K and 961-386261/917K from the Innovation Foundation of the State of Rhineland-Palatinate, by the Collaborative Research Center SFB 553 (Project A7 to HK), and the DFG grant Li 1759/1-1 (to HK). This study was partly supported

• Both DDRs are composed of an N terminal discoidin DS

  2020-07-31

  

  Both DDRs are composed of an N-terminal discoidin (DS) domain (Baumgartner et al., 1998), followed by a predicted DS-like domain (our unpublished results; Lemmon and Schlessinger, 2010), an extracellular juxtamembrane (JM) region, a transmembrane (TM) helix, a large cytosolic JM region, and a C-term

• We postulate that OT contained

  2020-07-31

  

  We postulate that OT contained in milk during early postnatal development causes a mild enteroprotective preconditioning of the ER (Fig 9). This is perhaps akin to a mechanism shown by others [50], [51], [52], which is characterized by selective activation of the IRE1a/XBP1/eIF2a (via PKR) UPR pathw

• Imaging of primary Tfh cells at the peak of

  2020-07-31

  

  Imaging of primary Tfh cells at the peak of the GC response revealed clear spatial segregation in the FM and GC compartments. This confinement was confirmed by TPP and discontinuous cell tracking 24 hr later, which showed retention of the majority of photoconverted GC Tfh cells in the original GC an

• br STAR Methods br Acknowledgments We thank M

  2020-07-31

  

  STAR★Methods Acknowledgments We thank M.C. Nussenzweig (The Rockefeller University) for B1-8hi mice, G.D. Victora (The Rockefeller University) and A. Kallies (University of Melbourne) for gene sets for the gene set enrichment analysis, K. Fukuhara (RIKEN) for help in performing digital RNA-seq

• Molecular basis of radioresistance involves many processes i

  2020-07-31

  

  Molecular basis of radioresistance involves many processes, including changes in growth factors and their receptors, different signaling and apoptotic pathways and DNA repair mechanisms . Whether higher tumor levels of DNA repair enzymes contribute to worse treatment results of GBM patients after po

• DGK metabolizes DG which enhances PKC

  2020-07-31

  

  DGK metabolizes DG, which enhances PKC activity [10,11]. DGKδ regulates the EGFR pathway for the epithelial cell differentiation of lungs and skin [27] and controls insulin receptor signaling for glucose uptake in skeletal muscle [20] by attenuating cnPKC activities. In this study, we found that the

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