• Any abnormality causing a loss

  2019-06-13

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• Clofarabine associated capillary leak syndrome attributed to

  2019-06-13

  

  Clofarabine-associated capillary leak syndrome, attributed to cytokine release, is characterized by hypotension, tachycardia, and tachypnea, and can be fatal. Alternatively, Type I hypersensitivity to clofarabine can occur in up to 5% of patients, and is also a contraindication to further therapy pe

• br The L type calcium channel LTCC in

  2019-06-12

  

  The L-type calcium channel (LTCC) in heart consists of 4 subunits: α1, β2, α2, and δ [47], encoded by CACNA1C, CACNB2, and CACNA2D, respectively, with the α2 and δ subunits encoded by the gene CANA2D. In 2007, Antzelevitch et al. [48] reported 2 CACNA1C mutations and a CACNB2 mutation from a genot

• Since many decades bone tumours have

  2019-06-12

  

  Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh

• liothyronine sodium There was a modest excess

  2019-06-12

  

  There was a modest excess risk of mortality associated with multidrug-resistant organisms, which was lower than that previously recorded in south Asia. There are methodological challenges in the attribution of excess neonatal mortality with antimicrobial resistance because of known confounding with

• The development in high income countries

  2019-06-12

  

  The development in high-income countries shows the possibilities for progress in twin health and survival: Danish twins born between 1870 and 1900 had higher early-life mortality rates than twins born in the late 20th century and contemporary sub-Saharan twins, with about 40% under-6 mortality (doub

• Another mechanism is that J waves represent a repolarization

  2019-06-12

  

  Another mechanism is that J waves represent a repolarization abnormality where J waves are created by the transmural voltage gradient [16]. During myocardial ischemia, the membrane ionic currents are known to be augmented, in turn augmenting the transient outward current (Ito). Augmented Ito would

• A recent meta analysis has shown

  2019-06-12

  

  A recent meta-analysis has shown that an enlarged LA increases the risk of AF recurrence after a single CPVI, regardless of the follow-up duration [5]. This finding can be applied to paroxysmal and persistent AF [6,7]. In clinical practice, measurement of LAD can provide a window into the status of

• It is noteworthy that in a recent study Le Scouarnec

  2019-06-12

  

  It is noteworthy that in a recent study, Le Scouarnec et al. [199]. estimated the burden of rare coding variation in arrhythmia susceptibility genes among 167 BrS index patients and compared that with 167 individuals ≥65 years old with no history of cardiac arrhythmia. The authors concluded that, ex

• ERS and BrS are thought

  2019-06-12

  

  ERS and BrS are thought to represent 2 manifestations of the JWSs. Both syndromes are associated with vulnerability to development of polymorphic VT and VF leading to SCD [1–3,15] in young adults with no apparent structural LY2584702 cost disease and occasionally to sudden infant death syndrome [25

• Paraguay es puntual en la

  2019-06-12

  

  Paraguay es puntual en la redacción del Artículo 8 de su Constitución Nacional cuando dice que “Las actividades susceptibles de producir alteración ambiental serán reguladas por la ley. Asimismo, ésta podrá restringir o prohibir aquéllas que califique peligrosas”. Describe allí las actividades que p

• br Materials and methods br Results br Discussion

  2019-06-11

  

  Materials and methods Results Discussion To our best knowledge, a multi-modality approach to systematically characterize an OS in vivo orthotopic model, using an aggressive OS cell line has not been previously reported. The advantage of using multi-modality approach i.e. BLI, histopathology

• ache inhibitor Esta idea se reforz con uno

  2019-06-11

  

  Esta idea se reforzó con uno de los elementos identitarios oficiales de la organización, su propio escudo. La comil tomó cuatro de las características reconocibles del pgt histórico; es decir, las siglas, la estrella, la hoz y el martillo, y el círculo que enmarcó todos estos símbolos, mismos que d

• Es importante subrayar que el

  2019-06-11

  

  Es importante subrayar que el recorte del corpus circunscrito al año 1939 también tiene su sustento historiográfico, es sabido que thymidylate synthase inhibitors partir de este momento se establece la figura del exiliado político. Asimismo, terminada la Guerra Civil española y habiéndose decretado

• A coordena o atestada de valores hoje considerados universai

  2019-06-11

  

  A coordenação atestada de valores hoje considerados universais em regulamentos, estatutos, editais e leis setoriais pelo mundo indica o esquema de convergência de motivos e razões, e figuras sociais e jurídicas, que remete a uma intensificação da comunicação entre as diversas partes do planeta, send

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