• We used two complementary methods MO based knockdown and cel

  2018-11-14

  

  We used two complementary methods, MO-based knockdown and cell transplantation, to generate zebrafish containing a spectrum of PGC numbers. Our findings revealed that a threshold number of PGCs is required for the stability of ovarian fate. Furthermore, no compensatory proliferation of germ gamma se

• br Introduction Cardiac morphogenesis results from the speci

  2018-11-14

  

  Introduction Cardiac morphogenesis results from the specification, differentiation, and migration of spatially and temporally distinct sets of cardiac precursor vascular disrupting agent that give rise to the mature cardiac tissue. The first multipotent cardiogenic cells originate from the mesod

• Experiments have revealed that the dolphin understands new

  2018-11-14

  

  . Experiments have revealed [31,32] that the dolphin understands new commands issued within artificial sign or sound language systems which use five-word-long sentences and interpreting which requires processing both the semantic and the syntactic rules of the language. These results, in our opinion

• br Cost Effectiveness of NOACs

  2018-11-14

  

  Cost Effectiveness of NOACs Cost effectiveness of the NOACs has been assessed in various studies. Despite the higher drug costs, rivaroxaban and dabigatran reduce overall medical costs compared to warfarin, unless the TTR for warfarin is above 65% and 70%, respectively. Apixaban has been estimate

• br Funding Association Fran aise contre

  2018-11-14

  

  Funding Association Française contre les Myopathies (AFM-Téléthon), French National Health Institute (INSERM), French National Research Agency (ANR), Bettencourt-Schueller Foundation, Cognacq Jay Foundation, Fondamental Foundation, Servier Laboratories. Role of the Funding Sources Aknowledg

• br There is increasing evidence of the important role of

  2018-11-14

  

  There is increasing evidence of the important role of innate immune system in tumor surveillance (). The spontaneous immune response of T XMU-MP-1 against tumors has a powerful prognostic value and can contribute to tumor control in patients. Indeed, T cell-based immunotherapies have shown to be e

• br Heating Up Immunologically Cold Tumours With

  2018-11-14

  

  Heating Up Immunologically Cold Tumours With an Oncolytic Virus As discussed our immune systems have evolved elaborate mechanisms to react against invading pathogens and rapidly mount immune responses to eliminate the pathogen and in some instances, the cells they infect. OVs are natural pathogen

• Thus age maturation affects speed of isoniazid acetylation b

  2018-11-14

  

  Thus, age (maturation) affects speed of isoniazid acetylation by modifying effect of genotype, a non-linear interaction, however after 5.3years the maturation is complete. Table 4 shows the BFs for NAT2 affinity for isoniazid, or Km. A child\'s height was the primary predictor and had the highest v

• This study has important limitations

  2018-11-14

  

  This study has important limitations. First, participants came from one academic medical center with its own patterns of clinic attendance, which may limit generalizability. The results may also differ by surgical specialty, which would be an interesting avenue for future investigation. Second, the

• br Introduction Neurofibromin Merlin NF

  2018-11-14

  

  Introduction Neurofibromin 2 (Merlin, NF2) is a tumour suppressor protein expressed during embryonic development and thereafter (Gronholm et al., 2005). In adults, significant levels of expression are found in Schwann and meningeal cells, nerve and lens (Claudio et al., 1997; Sakuda et al., 1996;

• br Experimental design materials and methods br Acknowledgme

  2018-11-14

  

  Experimental design, materials and methods Acknowledgments We are grateful for funding from ESRC under Grant reference no ES/K004824/1. We are also grateful for the services of the Secure Data Service support team. Specifications Table Value of the data Data The dataset consists of cross

• Our study had a number of limitations that should

  2018-11-14

  

  Our study had a number of limitations that should be addressed in future research. First, the study utilized a cross-sectional design to examine a developmental question. A longitudinal design would better control for individual differences in the sample. Second, it is possible that the task, parti

• Introduction Graph theory has been increasingly applied in t

  2018-11-13

  

  Introduction Graph theory has been increasingly applied in the analysis of connectivity in neuroimaging data. Graph-theory-derived centrality measures, especially eigenvector centrality (EVC), can rank the relevance of a node in a complex network (Zuo et al., 2012) in terms of strategic location. T

• br Estamos ante un proceso

  2018-11-13

  

  7. Estamos ante un proceso de larga duración. En el ya lejano 1986 lo definía Ernest Mandel —y no era el único— como “un proyecto político y social” del conjunto de las clases dominantes que trata de institucionalizar esta nueva relación de fuerzas entre los dueños del capital y los trabajadores

• Spearman rank order correlations between PSG and actigraphy

  2018-11-13

  

  Spearman rank-order correlations between PSG and actigraphy measures are presented in Table 3. Positive correlations were noted between PSG and both wrist actigraphy sleep summary measures (original: r=0.24–0.53, all pSenexin A cluster near the horizontal line, indicating small differences, and by m

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