• For this study a permanent coronary

  2018-11-08

  

  For this study, a permanent coronary artery ligation was performed in anesthetized animals and functional measurements were performed with open chest. In addition, we have not been able to investigate the effect of common comorbidities such as hypertension, dyslipidemia, and diabetes, which might in

• In summary our work is an important

  2018-11-08

  

  In summary, our work is an important step to understand and to control phosphorylation dynamics in human pluripotent stem cell maintenance and differentiation. This is the first report that provides a detailed analysis of MAPKs regulation in hESC in response to a small molecule inhibitor. We have sh

• The low percentage of overlap between

  2018-11-08

  

  The low percentage (10%) of overlap between RNA-Seq and ChIP-Seq datasets suggests an alternative role of THAP1 in regulating gene expression other than direct binding at DNA, as exists with other zinc-finger factors (Aguilo et al., 2015). This conclusion may also be supported by the relatively low

• ARN2966 BMSCs interfere with DC differentiation maturation

  2018-11-08

  

  BMSCs interfere with DC differentiation, maturation and function. IL-6 was initially thought as the main effector in the inhibition of DC differentiation by BMSCs. Djouda et al. reported that murine MSCs secreted high level of IL-6, which down-regulates the expression of MHC II, CD40, and CD86 on ma

• In contrast it is very surprising that N

  2018-11-08

  

  In contrast, it is very surprising that N-cad can confer a compact ES cell phenotype and is capable of participating in the MET process in our gene replacement approach. With the exception of its expression in the pseudostratified neuroepithelium, N-cad is usually associated with a mesenchymal unpol

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion An interesting discovery was that mTORC1 did not affect neurite density, as measured by neurite length divided by number of neurons, in the initial period in neuronal differentiation. Considering that the number of neurons did not change over time bu

• Several studies have shown a complex pattern of

  2018-11-08

  

  Several studies have shown a complex pattern of Ahr expression during early mouse embryogenesis. Fertilized eggs at the 1-cell stage show detectable levels of Ahr mRNA (Dey and Nebert, 1998; Wu et al., 2002) and high levels of AHR activity, as determined by an elevated constitutive mRNA level of the

• br Introduction Pancreatic ductal adenocarcinoma remains one

  2018-11-08

  

  Introduction Pancreatic ductal adenocarcinoma remains one of the most aggressive and devastating tumor malignancies with an overall 5-year survival rate of less than 5% (Kern et al., 2011). The only potentially curative treatment is the complete surgical resection of the tumor. Nevertheless, even

• br Materials and methods br Results br Discussion In

  2018-11-08

  

  Materials and methods Results Discussion In these experiments, we sought to determine the influence of gravitational mechanical unloading on the regenerative ability of bone marrow progenitors and specifically hypothesized that exposure to microgravity may alter the differentiation of bone

• Allogeneic non matched cloned male EGFP transduced porcine

  2018-11-08

  

  Allogeneic, non-matched, cloned male EGFP-transduced porcine eCSCs, were administered intracoronary in white Yorkshire female pigs, 30min after MI and coronary reperfusion (Ellison et al., 2009). Pig serum was injected to control pigs after MI (CTRL). The ganciclovir or sera were injected through a

• It is known that radiation also

  2018-11-08

  

  It is known that radiation also alters the SVZ microenvironment. Using a computed tomography-guided localized radiation technique, a study demonstrated that the intact SVZ NSCs failed to migrate across the irradiated RMS, suggesting that the microenvironment becomes hostile for cell invasion after r

• br Results br Discussion Human fetal dorsal skin from

  2018-11-08

  

  Results Discussion Human fetal dorsal skin, from which the fetal keratinocytes were cultured for this study, was analyzed histologically to correlate morphologic changes of the skin to biochemical changes in structural proteins during development. K18, which along with K8 is typical of simple

• In the controversial field of pluripotent stem cell research

  2018-11-08

  

  In the controversial field of pluripotent stem cell research, it is vital to argue on the basis of reliable and solid data that best reflect the actual research situation and are carefully validated. However, available data on recent research activities in this field are often based on abstract sear

• ALW-II-41-27 The laminins used in our

  2018-11-08

  

  The laminins used in our system were selected because of their importance in the developing ALW-II-41-27 (Domogatskaya et al., 2012; Miner et al., 2004), the regenerating liver (Martinez-Hernandez and Amenta, 1995; Carlsson et al., 1981), and the liver stem cell niche (Tanimizu et al., 2012; Lorenzi

• We believe that the production of homogeneous and functional

  2018-11-08

  

  We believe that the production of homogeneous and functional PSC-derived ventricular CMs using a non-transgenic approach will open new avenues for basic research and clinical applications. First, a pure population of ventricular CMs generated by the MB-based method offers a safer and more effective

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