• From a developmental perspective if hPSC

  2018-10-22

  

  From a developmental perspective, if hPSC-derived cardiomyocytes do show developmentally related changes, this system could provide a robust model for learning about the regulation of these changes during formation of the human heart. For example, fundamental details such as whether the increase in

• It is a generally accepted

  2018-10-22

  

  It is a generally accepted that adult-repopulating HSCs appear at E10.5–11 (Gekas et al., 2005; Medvinsky et al., 2011). At this stage, HSCs are considered to be rare and estimated to be less than one per single entire embryo (Gekas et al., 2005; Taoudi et al., 2008). A dramatic increase in the numb

• AMD-070 Previously we reported a chemical

  2018-10-22

  

  Previously, we reported a chemical genetic screen that revealed that several statins activate a β-catenin-responsive luciferase reporter (BAR) in a cell-based assay (Biechele et al., 2010). This result supports prior in vitro studies that have shown that statins modulate Wnt/β-catenin signaling (hen

• JNK signaling promotes the expression of cytoprotective

  2018-10-22

  

  JNK signaling promotes the expression of cytoprotective genes in flies, which contributes to tissue homeostasis loss in aged guts (Biteau et al., 2008). We found that JNK activity was increased in dbr- and ptc-depleted guts, and further inhibition of JNK activity in these guts effectively suppressed

• br Acknowledgments We thank Florence Le Calvez Kelm and

  2018-10-22

  

  Acknowledgments We thank Florence Le Calvez-Kelm and Geoffroy Durand from IARC\'s Genetics Platform (GPS) and Fabienne Barbet from the ProfileXpert platform for the processing and scanning of the Illumina 450K arrays. P.-B.A. was supported by la Ligue National (Française) Contre le Cancer. S.E. i

• This early dichotomy between generation of

  2018-10-22

  

  This early dichotomy between generation of blood and smooth muscle cyclin dependent kinase is further supported by previous studies indicating that while the transcription factor Tal1 (Scl) is critical for the development of hematopoietic cells (Porcher et al., 1996; Robb et al., 1996), it strongly

• Germ and somatic cells or pluripotent and differentiated cel

  2018-10-20

  

  Germ and somatic cells, or pluripotent and differentiated Tubastatin A HCl manufacturer can be distinguished on the basis of their epigenetic states (Boland et al., 2009; Okita et al., 2007; Takahashi and Yamanaka, 2006; Yamanaka, 2012). We previously demonstrated that epigenetic reprogramming foll

• One attractive strategy to improve outcome in heart failure

  2018-10-20

  

  One attractive strategy to improve outcome in heart failure is to regenerate damaged myocardium by making more functional cardiomyocytes. Extensive work over the past two decades has overturned the prevailing dogma that adult cardiomyocytes do not undergo cell division by demonstrating that adult ca

• The low density lipoprotein receptor related protein LRP fam

  2018-10-20

  

  The low-density lipoprotein receptor-related protein (LRP) family is an evolutionarily conserved group of cell-surface receptors that regulate diverse biological functions in different organs, tissues, and cell types, in mammals and species of other taxa (Strickland et al., 1994; Croy et al., 2003).

• A smaller number of differentially

  2018-10-20

  

  A smaller number of differentially expressed proteins between hiPSCs of different somatic origins, and less significant p-value associated with differentially regulated biological processes between them, than between hiPSCs and hESC, were observed. Besides, no statistically significant differentiall

• Living systems are constantly in

  2018-10-20

  

  Living systems are constantly in motion, and a changing magnetic field (MF) is associated with a changing electric field (EF). This has been shown via Faraday\'s Law, which states that a MF will interact with an electric circuit to produce an electromotive force. Endogenous pulsed EMF arises from th

• br Resource table Resource details We reprogrammed fibroblas

  2018-10-20

  

  Resource table Resource details We reprogrammed fibroblasts obtained from a patient with Familial Mediterranean Fever (FMF), an autosomal recessively inherited autoinflammatory disease caused by mutations in the MEFV gene (The International FMF Consortium, 1997; French FMF Consortium, 1997). Pat

• Introduction The stem cell subset contained within the

  2018-10-20

  

  Introduction The stem cell subset contained within the bone marrow stromal cell population (BMSCs, also known as bone marrow-derived mesenchymal stem cells) is characterized by self-renewal capacity, clonogenicity in vitro, multipotent differentiation into mesoderm-type faah including osteoblast,

• br Conclusion The following are the supplementary data relat

  2018-10-20

  

  Conclusion The following are the supplementary data related to this article. Conflict of interest Acknowledgements This work was supported by FONDECYT grant # 1130760 (P.C.). Introduction Peripheral vascular disease (PVD) due to arterial insufficiency is a common problem, affecting up

• On the other hand cell lines VUB and

  2018-10-20

  

  On the other hand, cell lines VUB01 and VUB14 showing the highest methylation grade, expressed more HLA-G mRNA compared to the low methylated cell lines VUB19_DM1 and VUB31_FSHD suggesting that next to promoter CpG methylation other mechanisms were involved in HLA-G expression control. Cis-regulator

15568 records 1037/1038 page Previous Next First page 上5页 103610371038