• The significant SNPs lie in non

  2018-11-09

  

  The significant SNPs lie in non-coding regions, as is common in GWAS where ~64% of identified SNPs lie in enhancer regions (Hnisz et al., 2013). Gene enhancer elements are noncoding segments of DNA involved in regulating transcriptional programs (Corradin and Scacheri, 2014). Their location is predi

• One thing that we learned in

  2018-11-09

  

  One thing that we learned in the presented ZIKV vaccine studies is that the yield of production of the ZIKV envelope E subunit protein was very low in the current format. This finding, also confirmed by a recently published ZIKV vaccine study (Larocca et al., 2016), is similar to what was previously

• Both the active and passive moisture sensors HIH

  2018-11-09

  

  Both the active and passive moisture sensors (HIH4031 and HCZ-D5) showed reliable and repeatable performance during experiments with and without the applied bandage. The active sensor showed a faster response as compared to that of the passive sensor. Moreover, it does not require any additional int

• br Materials and methods br

  2018-11-09

  

  Materials and methods Results Microfluidic analytical devices with optical detection are considered one of the best options for developing robust and sensitive lab-on-chip devices. Key features for diagnostic and prognostic usefulness of such devices are high sensitivity and specificity, abili

• The median poverty rate was from to

  2018-11-09

  

  The median poverty rate was 13.4% from 1959 to 2012 (horizontal dashed line in Figure 1). It is clear that after the 1980\'s, the US mitotic inhibitor has been well above that point (see Figure 1). It can be noted that the best way to describe the growth rates of poverty in the United States is a l

• br The Concept of Poverty and Its Causes There are

  2018-11-09

  

  The Concept of Poverty and Its Causes There are two ways to approach the concept of poverty in conventional theories. First of all, some researchers refuse to deal with the concept. For example, some scholars think that the concept is elusive and impossible to grasp because the meaning depends on

• Ricardo s letter of June to McCulloch was mentioned

  2018-11-09

  

  Ricardo\'s letter of 18 June 1821 to McCulloch was mentioned in J.M. Keynes\'s rejection letter (dated 9 January 1924) to Wicksell, upon submission to the Economic Journal of a manuscript titled “Ricardo on machinery and the present unemployment” (Jonung, 1981, p. 199). Keynes referred to that lette

• br Results br Discussion Geography can either limit or

  2018-11-09

  

  Results Discussion Geography can either limit or facilitate the spread of infectious diseases, like HIV. The proximity and close cultural ties between populations in Mexico and the southwestern US, have linked these groups for many years. Thus, it is not surprising that in the early days of th

• nf-κb inhibitor br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion The present study clearly demonstrates anti-oxidant potential of A. calamus extracts as shown by inhibition of generation of free radicals, protection of DNA and mitochondria from oxidative damage as revealed by different in vitro assays and preventi

• For this study a permanent coronary

  2018-11-08

  

  For this study, a permanent coronary artery ligation was performed in anesthetized animals and functional measurements were performed with open chest. In addition, we have not been able to investigate the effect of common comorbidities such as hypertension, dyslipidemia, and diabetes, which might in

• In summary our work is an important

  2018-11-08

  

  In summary, our work is an important step to understand and to control phosphorylation dynamics in human pluripotent stem cell maintenance and differentiation. This is the first report that provides a detailed analysis of MAPKs regulation in hESC in response to a small molecule inhibitor. We have sh

• The low percentage of overlap between

  2018-11-08

  

  The low percentage (10%) of overlap between RNA-Seq and ChIP-Seq datasets suggests an alternative role of THAP1 in regulating gene expression other than direct binding at DNA, as exists with other zinc-finger factors (Aguilo et al., 2015). This conclusion may also be supported by the relatively low

• ARN2966 BMSCs interfere with DC differentiation maturation

  2018-11-08

  

  BMSCs interfere with DC differentiation, maturation and function. IL-6 was initially thought as the main effector in the inhibition of DC differentiation by BMSCs. Djouda et al. reported that murine MSCs secreted high level of IL-6, which down-regulates the expression of MHC II, CD40, and CD86 on ma

• In contrast it is very surprising that N

  2018-11-08

  

  In contrast, it is very surprising that N-cad can confer a compact ES cell phenotype and is capable of participating in the MET process in our gene replacement approach. With the exception of its expression in the pseudostratified neuroepithelium, N-cad is usually associated with a mesenchymal unpol

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion An interesting discovery was that mTORC1 did not affect neurite density, as measured by neurite length divided by number of neurons, in the initial period in neuronal differentiation. Considering that the number of neurons did not change over time bu

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