• Based on the ability to derive hESC lines

  2018-11-14

  

  Based on the ability to derive hESC lines with an extra copy of a particular chromosome, the different trisomies can be divided in two groups. One group comprises trisomies for those chromosomes found to be present in blastomeres by PGS, but unlikely to survive as trisomic ESC lines. This is the cas

• Introduction The stem cell niche is a unique microenvironmen

  2018-11-14

  

  Introduction The stem cell niche is a unique microenvironment that maintains long-term repopulation of a specific tissue by undergoing self-renewal of stem adenylate cyclase and by producing progenies of increasingly differentiated cells. A large amount of knowledge concerning the regulation of ste

• Concomitant with its suppressive effect on

  2018-11-14

  

  Concomitant with its suppressive effect on blast colony formation, the inclusion of WNT3A, or the WNT agonist BIO, in methylcellulose cultures promoted the emergence of colonies we termed “mesospheres” (Figure 7H). These colonies were capable of osteogenic, adipogenic, and smooth muscle differentiat

• We hypothesized that type B

  2018-11-14

  

  We hypothesized that type B astrocytes might be among the other SVZ-derived cell types able to migrate in response to a damage insult. In this study we used Nilo1, a previously characterized mAb that identifies early neural progenitors in the SVZ niche (Del Valle et al., 2010), demonstrating that Ni

• We used two complementary methods MO based knockdown and cel

  2018-11-14

  

  We used two complementary methods, MO-based knockdown and cell transplantation, to generate zebrafish containing a spectrum of PGC numbers. Our findings revealed that a threshold number of PGCs is required for the stability of ovarian fate. Furthermore, no compensatory proliferation of germ gamma se

• br Introduction Cardiac morphogenesis results from the speci

  2018-11-14

  

  Introduction Cardiac morphogenesis results from the specification, differentiation, and migration of spatially and temporally distinct sets of cardiac precursor vascular disrupting agent that give rise to the mature cardiac tissue. The first multipotent cardiogenic cells originate from the mesod

• Experiments have revealed that the dolphin understands new

  2018-11-14

  

  . Experiments have revealed [31,32] that the dolphin understands new commands issued within artificial sign or sound language systems which use five-word-long sentences and interpreting which requires processing both the semantic and the syntactic rules of the language. These results, in our opinion

• br Cost Effectiveness of NOACs

  2018-11-14

  

  Cost Effectiveness of NOACs Cost effectiveness of the NOACs has been assessed in various studies. Despite the higher drug costs, rivaroxaban and dabigatran reduce overall medical costs compared to warfarin, unless the TTR for warfarin is above 65% and 70%, respectively. Apixaban has been estimate

• br Funding Association Fran aise contre

  2018-11-14

  

  Funding Association Française contre les Myopathies (AFM-Téléthon), French National Health Institute (INSERM), French National Research Agency (ANR), Bettencourt-Schueller Foundation, Cognacq Jay Foundation, Fondamental Foundation, Servier Laboratories. Role of the Funding Sources Aknowledg

• br There is increasing evidence of the important role of

  2018-11-14

  

  There is increasing evidence of the important role of innate immune system in tumor surveillance (). The spontaneous immune response of T XMU-MP-1 against tumors has a powerful prognostic value and can contribute to tumor control in patients. Indeed, T cell-based immunotherapies have shown to be e

• br Heating Up Immunologically Cold Tumours With

  2018-11-14

  

  Heating Up Immunologically Cold Tumours With an Oncolytic Virus As discussed our immune systems have evolved elaborate mechanisms to react against invading pathogens and rapidly mount immune responses to eliminate the pathogen and in some instances, the cells they infect. OVs are natural pathogen

• Thus age maturation affects speed of isoniazid acetylation b

  2018-11-14

  

  Thus, age (maturation) affects speed of isoniazid acetylation by modifying effect of genotype, a non-linear interaction, however after 5.3years the maturation is complete. Table 4 shows the BFs for NAT2 affinity for isoniazid, or Km. A child\'s height was the primary predictor and had the highest v

• This study has important limitations

  2018-11-14

  

  This study has important limitations. First, participants came from one academic medical center with its own patterns of clinic attendance, which may limit generalizability. The results may also differ by surgical specialty, which would be an interesting avenue for future investigation. Second, the

• br Introduction Neurofibromin Merlin NF

  2018-11-14

  

  Introduction Neurofibromin 2 (Merlin, NF2) is a tumour suppressor protein expressed during embryonic development and thereafter (Gronholm et al., 2005). In adults, significant levels of expression are found in Schwann and meningeal cells, nerve and lens (Claudio et al., 1997; Sakuda et al., 1996;

• br Experimental design materials and methods br Acknowledgme

  2018-11-14

  

  Experimental design, materials and methods Acknowledgments We are grateful for funding from ESRC under Grant reference no ES/K004824/1. We are also grateful for the services of the Secure Data Service support team. Specifications Table Value of the data Data The dataset consists of cross

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