• Studies have demonstrated that AT plays

  2023-08-31

  

  Studies have demonstrated that AT2 plays a greater role in modulating arterial pressure in females than in males. Chronic low-dose infusion of Ang II decreased blood pressure in female rats at a dose that had negligible effects in males. Furthermore, AT2 blockade eliminates the depressor response to

• It has been reported that trehalose shows beneficial effects

  2023-08-31

  

  It has been reported that trehalose shows beneficial effects in a mouse model of several neurodegenerative diseases [21], [22], [23]. There are also reports showing that trehalose can improve the impaired cognitive and learning ability and reduced Aβ deposit in hippocampus of APP/PS1 transgenic mice

• Another important finding of our study is

  2023-08-31

  

  Another important finding of our study is the observation that high glucose per se does not affect TER in mature HREC monolayers; but at the same time it does upregulate ICAM-1 directly and activates HRECs to leukocyte adhesion. This would imply that high glucose affects TER in mature HREC monolayer

• The cavity volume of the binding pocket

  2023-08-31

  

  The cavity volume of the binding pocket may differ not only between species but also among various AhR/ARNT isoforms within a single species. It is noteworthy that even a single amino ABT substitution within a binding pocket may result in a change in the cavity volume. This, in turn, may affect the

• Ketogenic diets are more effective in

  2023-08-31

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

• br Conclusion The HT receptor family is

  2023-08-31

  

  Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless RK-33 (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological function); molecular biology has

• The total IgG concentration decreased from a mean of

  2023-08-30

  

  The total IgG concentration decreased from a mean of 997 mg/100 ml before treatment to a mean of 696 after treatment in the MuSK+MG patients, and from a mean of 1736 mg/100 ml to a mean of 802 mg/100 ml in the AChR+MG patients (normal values 723–1685 mg/100 ml). This decrement was also statistically

• Because serum ATX activity and plasma LPA

  2023-08-30

  

  Because serum ATX activity and Cy5 EGFP mRNA LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, LPA can incr

• Of note core autophagy factors also play an

  2023-08-30

  

  Of note, core autophagy factors also play an important role during the infection of host cells by another type of picornavirus, namely, echovirus 7. ATG16L1 was found necessary for entry/internalization into Caco-2 polarized epithelial cells because the virus accumulated on the surface of ATG16L1-de

• If the lack of specificity and

  2023-08-30

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Iodophenpropit dihydrobromide may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic intervent

• Aurora kinases are a conserved family of serine threonine ki

  2023-08-30

  

  Aurora kinases are a conserved family of serine/threonine kinases that are important for the transition through mitosis and amplification and overexpression of Aurora kinases have been implicated in inos inhibitor and transformation. Aurora B is located at the centromere and controls aspects of kin

• br Experimental Procedures Additional information

  2023-08-30

  

  Experimental Procedures Additional information can be found in Supplemental Experimental Procedures. Author Contributions Acknowledgments We thank all members of Lab of Health Chemistry for helpful discussions. This work was supported by Grant-in-Aid for Scientific Research (KAKENHI) from

• Introduction Hepatocellular carcinoma HCC is one of the most

  2023-08-30

  

  Introduction Hepatocellular carcinoma (HCC) is one of the most difficult cancers to treat, and it threatens human health severely [1]. Although various interventions, including surgical operation, radiofrequency ablation, and chemotherapy, have been endorsed, the prognosis of HCC patients remains p

• br Apelin The APJ receptor ligand apelin firstly

  2023-08-30

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino L-817,818 mg residues that are cleaved into biologically active C-terminal fragments of various s

• Several mechanisms of Cd induced

  2023-08-30

  

  Several mechanisms of Cd-induced carcinogenicity have been reported and are comprehensively summarized by Hartwig [32]. As early as 1980, basic science studies supported a role for endocrine disruption of AR by Cd. Donovan et al. [33], using extracts of mouse prostate cytosol, showed Cd to be the mo

16067 records 294/1072 page Previous Next First page 上5页 291292293294295 下5页 Last page