• br Experimental procedures br Results Hdc

  2022-01-26

  

  Experimental procedures Results Hdc-KO mice show basal activation of the MAPK and AKT/GSK3β pathways in the dorsal striatum (Rapanelli et al., 2014). These signaling pathways are differentially regulated by the H3 receptor in dMSNs and iMSNs in wild-type mice (Rapanelli et al., 2016). To bette

• br Intracellular trafficking with concurrent signaling of

  2022-01-26

  

  Intracellular trafficking with concurrent signaling of NPRA Our recent studies have shown internalization and concurrent signaling of NPRA in subcellular compartments; this had not been previously demonstrated [26,42]. Preparation of the enhanced GFP (eGFP)-tagged NPRA (eGFP-NPRA) construct has g

• Introduction Multiple sclerosis MS a neurological

  2022-01-26

  

  Introduction Multiple sclerosis (MS), a neurological autoimmune disease, is driven by CD4+ WZB117 of the T helper (TH) cells [1]. There is no curative treatment for MS and the present treatments typically focus on immunomodulation for slowing the progression of the disease. These includes interfer

• br Experimental section br Introduction Fasting

  2022-01-25

  

  Experimental section Introduction Fasting hyperglycaemia in all forms of diabetes mellitus occurs primarily as a result of upsurge in hepatic glucose synthesis (HGS) [1], [2]. Two specific enzymes, glucokinase (GK) and glucose-6 phosphatase (Glu-6-Pase) play crucial role in hepatic glucose pro

• As early as glucagon was shown to increase energy expenditur

  2022-01-25

  

  As early as 1957, glucagon was shown to increase agomelatine receptor expenditure in rodents in both pair-feeding studies and through directly increasing oxygen consumption [23], [24]. This has more recently been confirmed in man, through indirect calorimetry during glucagon infusions [25], [26], [

• While CART increased circulating levels of GIP and

  2022-01-25

  

  While CART increased circulating levels of GIP and GLP-1 in vivo, we were unable to detect any effect of exogenous CART on GIP and GLP-1 mRNA expression or GLP-1 secretion in vitro. There is no ready explanation for this discrepancy. The CART doses used (both in vivo and in vitro) have been shown to

• The effect of GC on

  2022-01-25

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 unlikely was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secretion [28]. In

• br Results br Discussion Our studies highlight MUFAs

  2022-01-25

  

  Results Discussion Our studies highlight MUFAs as key lipid modulators of both non-apoptotic and apoptotic cell death. Recent studies show that a more mesenchymal phenotype, de-differentiation, and acquired resistance to targeted inhibitors, can all promote a ferroptosis-sensitive cell state (

• In analyzed alleles in this study the c C

  2022-01-25

  

  In 3/11 analyzed Bilirubin mg in this study, the c.472C>T missense variant was detected. This variant was previously reported in Malaysian, French, Indian and Pakistani patients (Bhai et al., 2018; Ijaz et al., 2017; Lebigot et al., 2015; Moey et al., 2018; Ngu et al., 2014) who were homozygous and

• Data are expressed as means SE Statistical significance

  2022-01-25

  

  Data are expressed as means±SE. Statistical significance was determined by the Student's -test or ANOVA with post hoc Bonferroni test. A value of A-1155463 australia expressing human FPPS. Western blot analysis showed a clear band, which indicated the overexpression of FPPS, in U87MG cells (A, inse

• Data of initial analogs have been shown in wherein SAR

  2022-01-25

  

  Data of initial analogs (±)-– have been shown in wherein SAR was observed for the intended change of the right-hand side pyridin-3-yl ring of to various other -containing heteroaryl ring (Ar) disposing the ring- at different directions. Based on consistent human and rat FAAH potency as well as int

• Recently results obtained by our

  2022-01-25

  

  Recently, results obtained by our group have demonstrated that hEECs are able to secrete NPY into the extracellular medium and that this peptide can induce an increase in the [Ca]i of these cells (Jacques et al., 2003b). In light of these results and those obtained in this study, we can speculate th

• The Jumonji JmjC domain containing KDM family members can be

  2022-01-25

  

  The Jumonji (JmjC) domain-containing KDM family members can be clustered into seven subfamilies (KDM2 – KDM8). The KDM2 cluster catalyzes H3K36me2/me1 demethylation; in addition, KDM2B/JHDM1B/FBXL10 has been suggested to catalyze demethylation of H3K4me3 [3]. Cell culture studies support that KDM2 p

• Third across all three signaling

  2022-01-25

  

  Third, across all three signaling molecules examined, the baseline abnormalities seen in Hdc-KO mice resemble the effects seen after H3R activation in wild-type animals. Specifically, MAPK activity (indexed by MSK1 phosphorylation) is increased at baseline in dMSNs of Hdc-KO mice to a similar degree

• In conclusion studies of the regulation of the HO BVR

  2022-01-25

  

  In conclusion, studies of the regulation of the HO-1/BVR/CO pathway by selective pharmacological approaches may lead to the discovery of novel compounds for the treatment of diverse diseases. Recent results validate the use of advances in targeting HO-1 in various vascular diseases. However, there a

15911 records 491/1061 page Previous Next First page 上5页 491492493494495 下5页 Last page