• In analyzed alleles in this study the c

  2021-12-16

  

  In 3/11 analyzed caspofungin in this study, the c.472C>T missense variant was detected. This variant was previously reported in Malaysian, French, Indian and Pakistani patients (Bhai et al., 2018; Ijaz et al., 2017; Lebigot et al., 2015; Moey et al., 2018; Ngu et al., 2014) who were homozygous and c

• Zanamivir The product chain length determination

  2021-12-16

  

  The product chain-length determination mechanism of -prenyltransferases has not yet been elucidated, although mutational analyses of highly conserved residues and of characteristic amino Zanamivir residues in each subfamily of -prenyltransferases have enabled the understanding of the basic catalyti

• In order to establish proper

  2021-12-16

  

  In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both Cefepime Dihydrochloride Monohydrate synthesis contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cyst

• br Ethical approve and consent to participate

  2021-12-16

  

  Ethical approve and consent to participate Consent for publication Availability of supporting data Competing interests Funding This work was supported by a grant from Key Program of National Natural Science Foundation of China (No. 81330089) and the Shanghai Science and Technology Fun

• Introduction Hepatocellular carcinoma HCC is the fifth most

  2021-12-16

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, N-Benzylacetamidine hydrobromide virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2],

• br Soluble guanylyl cyclase nitric oxide

  2021-12-16

  

  Soluble guanylyl cyclase, nitric oxide and nitric oxide synthase The primary and best-studied endogenous activator of soluble guanylyl cyclase (sGC) is nitric oxide (NO), which was originally describe as endothelium-derived relaxing factor for its potent ability to relax blood vessels in response

• The gsnor ko plants contain elevated

  2021-12-16

  

  The gsnor-ko plants contain elevated amount of low and high molecular weight S-nitrosothiols (SNO) indicating that GSNOR activity controls the level of both GSNO and indirectly protein-SNOs [13], [17], [18]. GSNOR deficiency has been shown to cause pleiotropic plant growth defects, impaired plant di

• In summary we have successfully identified a series of

  2021-12-16

  

  In summary, we have successfully identified a series of potent and selective GSNOR inhibitors having imidazole and tetrazole functional groups in both end of the core structure and many compounds have been identified with IC: Introduction Peppers (Capsicum annuum L.), tomatoes and potatoes, belon

• br Cholecystokinin CCK CCK is

  2021-12-16

  

  Cholecystokinin (CCK) CCK is secreted by enteroendocrine I-cells of the duodenum and jejunum in response to amino acids and lipids [14]. There are two forms of the CCK receptor, CCK1 which is expressed on pancreatic α- and β-cells while CCK2 is located on somatostatin-secreting δ-cells [8]. CCK r

• Introduction Glycine Fig has two pivotal

  2021-12-16

  

  Introduction Glycine (Fig. 1; 1) has two pivotal functions as neurotransmitter in the central nervous system (CNS). Firstly, it can act as an inhibitory neurotransmitter at inhibitory glycinergic synapses where it binds to the strychnine-sensitive glycine-A binding site on glycine receptors (GlyR)

• One of the main clinical issues of

  2021-12-16

  

  One of the main clinical issues of ABCB1, together with its impact on intestinal absorption, concerns its location at the BBB. Indeed, ABCB1 has been identified in the luminal side of endothelial cells and in the abluminal side of astrocyte endfeet processes of the CNS microvasculature [[36], [37],

• br Methods br Results Top panels

  2021-12-16

  

  Methods Results Top panels of the Fig. 1 show the conventional representation of the predicted values of TL,CO according to ERS’93 and GLI′17 as a function of age and keeping the height constant (160 cm, panel A and 190 cm, panel B). This figure shows that the GLI-‘17 predicted values of TL,CO

• Initially we carried out gap

  2021-12-16

  

  Initially, we carried out gap-FRAP experiments using the two-photon configuration of the confocal microscope. A SR101-positive astrocyte was targeted and a 5 × 5 μm square area was exposed to a laser illumination (5 flashes of 5 s each during 25 s). This procedure resulted in a bleaching of this ast

• SLIGKV-NH2 br Declarations of interest br Acknowledgements T

  2021-12-16

  

  Declarations of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81673321, 21506099), the State Key Laboratory of Drug Research (SIMM1705KF-13), the Natural Science Foundation of Jiangsu Province (Grant No. BK20151541), and the Jiangsu Syne

• br Funding This study was supported by

  2021-12-15

  

  Funding This study was supported by grants-in-aid for scientific research from the Japan Society for Promotion of Science (grant 16K186462 to Dr. Tomizawa, grant 16K19989 to Dr. Kobayashi, and grant 16H05433 to Dr. Mitsudomi) and a research grant from Boehringer-Ingelheim (to T. Mitsudomi). Co

15911 records 517/1061 page Previous Next First page 上5页 516517518519520 下5页 Last page