• The proliferation of CCA cell lines

  2021-06-07

  

  The proliferation of CCA cell lines can be stimulated by estrogen and other growth factors (Alvaro et al., 2006; DeMorrow, 2009; Mancino et al., 2009). It has also been reported that estrogen positively modulates cholangiocyte proliferation, which is associated with cholangiopathies found in humans

• Notably we demonstrated that EP EP receptor coupled

  2021-06-05

  

  Notably we demonstrated that EP2/EP4 receptor-coupled activation of the cAMP signaling pathway accounted for both up-regulation of COX-2 and down-regulation of LOX, which is consistent with the roles of the cAMP signaling pathway in regulation of COX-2 and LOX by PGE2 in a number of other tissues or

• The rate of protein degradation is often affected

  2021-06-05

  

  The rate of protein degradation is often affected by N-starvation [12], therefore, we examined the influence of N-starvation against the appearance of CEPs. N-starved cucumber cotyledons contained less amounts of protein and Rubisco, but the temporal changes in protein and Rubisco contents were simi

• Aminothiazole derivatives have been reported to contain

  2021-06-05

  

  2-Aminothiazole derivatives have been reported to contain antiviral [17], anti-inflammatory [18], and antimicrobial [19] activities. The in vitro anticancer studies showed that different 2-aminothiazole derivatives possess selective and potent inhibitory effect against wide-ranging human cancerous c

• adenosine diphosphate Methods br Results br Discussion In

  2021-06-05

  

  Methods Results Discussion In this study we make the novel observation that villin-1 and gelsolin are down-regulated in response to diverse cellular stressors, including bacteria associated with the pathogenesis of CD. The high plasticity and dynamics of the adenosine diphosphate cytoskeleton

• br Materials and methods br Results br Discussion

  2021-06-05

  

  Materials and methods Results Discussion Macrophages and dendritic cells respond to Toll-like receptor (TLR) ligands by upregulating CH25H expression [4], [5]. In the latter cell type TLR-dependent upregulation is mediated via a signalling pathway that involves NFκB and IFNβ secretion and c

• br A brief history of RBR E s RBR E

  2021-06-05

  

  A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains: two RING domains (RING1 and RING2) connected via an in-between-RING (IBR) domain [28], [29]. The prediction together with initial observati

• CAA is a carcinogenic metabolite of vinyl chloride

  2021-06-05

  

  CAA is a carcinogenic metabolite of vinyl chloride, forming several different DNA adducts including the cyclic Genomic DNA Isolation Kit australia adducts 3,N4-ethenocytosine (εC), 1,N6-ethenoadenine (εA), N2,3-ethenoguanine (εG), and 1,N2-ethenoguanine (1,N2-εG), with the A and C cyclic adducts th

• Testosterone is inactivated through hydroxylation and

  2021-06-05

  

  Testosterone is inactivated through hydroxylation and conjugation pathways [3], [4]. 6β-Hydroxylation is the main pathway among testosterone hydroxylation processes in the liver microsome. Testosterone 6β-hydroxylation is mainly catalyzed by cytochrome P450 3A (CYP3A) [5], [6], which is expressed in

• Currently no evidence supports pathogenic variants in exons

  2021-06-05

  

  Currently, no evidence supports pathogenic variants in exons 20, 21, and 22, which are part of transcript isoform hCDKL5_5, or within exon 17, which is part of transcript isoform hCDKL5_2. The pathogenicity of variants in the 5′ untranslated region remain uncertain except for deletions extending to

• Based on the finding described above the present study was

  2021-06-04

  

  Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 ticarcillin antagonist CP

• Several mechanisms are implicated in lipid induced

  2021-06-04

  

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012). Mitochondrion is a major source of ROS production. The oxidation of pyruvate and fatty dexamethasone acetate yielding acetyl-

• The proposed FDIR technique is presented in the

  2021-06-04

  

  The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the 2 nbdg environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estimated is pres

• Activating GSK signaling to inhibit

  2021-06-04

  

  Activating GSK3β signaling to inhibit PK signaling during ischemia/reperfusion (I/R) is protective of WM ischemic injury. Glycogen synthase kinase (GSK3), which was the first substrate identified for AKT [44], is inhibited by AKT phosphorylation at positions S9 and S21 [45]. When GSK3β is active, it

• The mechanism underlying the increased PON levels found in

  2021-06-04

  

  The mechanism underlying the increased PON1 levels found in greenhouse workers may be accounted for by an increased protein fosaprepitant dimeglumine synthesis following pesticide interaction with different nuclear receptors as also occurs with other chemicals, such as polyphenols and statins [28].

15911 records 630/1061 page Previous Next First page 上5页 626627628629630 下5页 Last page