• The objective of the present

  2020-04-26

  

  The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in glycerophosphate regions belonging to the reward pathway using a

• The ubiquitin proteasome system Ub P is the main

  2020-04-26

  

  The ubiquitin–proteasome system (Ub–P) is the main cellular machinery for protein turnover in eukaryotic cells (Glickman and Ciechanover, 2002). Degradation by Ub–P involves two steps. Target proteins are selectively, specifically, and covalently attached to ubiquitin (Ub) chains, followed by Ub-tag

• appreciate The present study is a

  2020-04-26

  

  The present study is a genetic association study using the classic candidate gene approach. This method has been repeatedly criticized in the past to produce highly unreliably findings (e.g. Flint & Munafò, 2013). The alternative would be the conduction of a appreciate wide association study (GWAS)

• As the first allotetraploid fish

  2020-04-26

  

  As the first allotetraploid fish in the world, our lab selectively breed the allotetraploid hybrid fish (4nAT, 4n = 200) from the distant hybridization offspring F3 of female Red Crucian Carp (Carassius auratus red var., abbreviated as RCC, 2n = 100) and male Common Carp (Cyprinius carpio L., abbrev

• br Type II NAD P

  2020-04-26

  

  Type II NAD(P)H Dehydrogenases in Fungi Fermentative YeastSaccharomyces cerevisiaeBecause S. cerevisiae is a facultative Kif15-IN-1 yeast capable of meeting its energy requirements with ATP generated by fermentation, only relatively few mitochondrial proteins are essential for cell viability. Th

• The data from drug screening in P

  2020-04-26

  

  The data from drug screening in P. berghei (Fig. 3D) provide proof of concept that chemogenomic profiling can be accomplished in P. berghei in the same manner as P. falciparum, in that significant increases in the EC50 ratio were found only for antifolate drugs in the parasite with attenuated TgDHF

• Kobe0065 br Neuroimaging Neuroimaging has not yet been syste

  2020-04-26

  

  Neuroimaging Neuroimaging has not yet been systematically reported in individuals with CDD, although case reports document normal Kobe0065 anatomy or less often, show cortical atrophy or T2 fluid-attenuated inversion recovery hyperintensities in the white matter.15, 17, 18, 19, 48, 52, 54, 55, 6

• br Materials and methods br Results

  2020-04-26

  

  Materials and methods Results and discussion Conclusions Given that the activity of anti-plant virus compounds is related to host tobacco, virus, and compounds, we determined the effect of anti-CMV compound NNM on defense enzyme activity and chlorophyll index in tobacco, and we used RIB as

• The synthesis of the required substrates is shown in see

  2020-04-26

  

  The synthesis of the required substrates is shown in (see for experimental details). Treatment of heterocycle with Santacruzamate A mg under basic conditions afforded a mixture of the mono-substituted product (22%) and the di-substituted compound (38%) which were separated by column chromatog

• br Materials and methods br Results We examined

  2020-04-26

  

  Materials and methods Results We examined the effects of curcumin in Fluo-4 loaded SH-EP1 MnTBAP Chloride stably transfected with human α7-nACh receptor. Application of curcumin alone in the concentrations up to 100 μM for 30 sec. did not induce any detectable change in intracellular Ca2+ leve

• Similarly to other investigations the present study

  2020-04-26

  

  Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer ido1 inhibitor (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA observed b

• Imatinib STI is a first line tyrosine kinase inhibitor TKI

  2020-04-26

  

  Imatinib (STI-571) is a first-line tyrosine kinase inhibitor (TKI) targeted at breakpoint cluster region-Abelson kinase (ABL) for the treatment of chronic myeloid leukemia (CML) [26]. As a type II inhibitor, imatinib achieves significant selectivity by binding to an inactive DFG-out conformation (DF

• br Materials and methods br Results and discussion br Summar

  2020-04-26

  

  Materials and methods Results and discussion Summary Acknowledgments We thank Muhammad Anwar for animal rearing and surgery. We also thank Michael M. Myers for editing. Finally, we thank David Hirschberg for his technical advice. Funding for this project was provided by the Einhorn Famil

• Introduction The Discoidin Domain Receptors DDRs comprising

  2020-04-24

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• Patients with a tumor of cm or

  2020-04-24

  

  Patients with a tumor of 4 cm or greater were more likely to have lymph node or tumor metastasis (Fisher’s test p = 0.0001 and 0.0003, respectively). In this smaller patient group a significant correlation between higher DAPK-1 mRNA naloxone hcl in tumor and normal tissue in tumor-free patients comp

16080 records 853/1072 page Previous Next First page 上5页 851852853854855 下5页 Last page