• In conclusion we have identified

  2019-07-23

  

  In conclusion, we have identified Ednra as a downstream direct target of Hoxa9 and Meis1. Upregulation of Ednra has a role in the progression of Hoxa9+Meis1-induced leukemia and targeting Ednra together with other chemotherapies may have therapeutic benefits for leukemia [30]. Ednra inhibitors in th

• Numerous studies have investigated the

  2019-07-23

  

  Numerous studies have investigated the contribution of N-cadherin to metastasis and tumorigenesis. The overexpression of N-cadherin has been shown to enhance tumor invasion and motility in multiple cancer models [25,40,48]. Transforming growth factor beta 1 (TGFβ1) is a strong EMT inducer. In fact,

• The in vitro enantioselective metabolism of pesticides

  2019-07-23

  

  The in vitro enantioselective metabolism of pesticides has been investigated by employing human liver microsomes, which are a reliable resource to perform MCL enantioselective risk assessment in humans (Carrão et al., 2019; de Albuquerque et al., 2018, 2016; Yao et al., 2016). The enantioselective m

• In a study carried out

  2019-07-23

  

  In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in 5-EdU to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots were obtained

• In the brain E can modulate the mitogen

  2019-07-22

  

  In the brain, E2 can modulate the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway, which is involved in the formation of different memory types (Atkins et al., 1998, Blum et al., 1999, Schafe et al., 2000). When the MAPK/ERK signaling pathway is activated,

• Fujimoto et al pointed out that RPN knockout alleviated the

  2019-07-22

  

  Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC BAY 41-2272 solubility (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irinotecan, docetaxel, doxor

• LiCl Previous in vitro and in vivo

  2019-07-22

  

  Previous in vitro and in vivo studies have shown the potent ability of toll-like receptor (TLR) ligands and type I interferon (IFN) signaling to induce CH25H in macrophages and DCs following exposure to innate immune stimuli (Bauman et al., 2009; Diczfalusy et al., 2009; Park and Scott, 2010; Zou et

• Despite its significance in tumor suppression the molecular

  2019-07-22

  

  Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled. Although primarily regulated by CaM binding (Cohen et al., 1997), DAPK activity can also be modulated

• Although the presence of calcium in RHA P active

  2019-07-19

  

  Although the presence of calcium in RHA-P active site is confirmed by the homology modeling, some additional observations can be made following the metal depletion and reconstitution experiments performed on RHA-Phis. EDTA-treated RHA-Phis recovers its activity in the presence of divalent cations su

• br Acknowledgements Professor Olli A J nne is warmly

  2019-07-19

  

  Acknowledgements Professor Olli A. Jänne is warmly thanked for support and for providing excellent research facilities. Professor Patrik Finne is acknowledged for his help with statistical analyses. Drs Ronald Evans, Vincent Giguère, Jorma Palvimo, Malcolm Parker, and Anastasia Kralli are acknowl

• br EphB as a therapeutic target in cancer

  2019-07-19

  

  EphB4 as a therapeutic target in cancer Eph receptors and ephrins are promising new therapeutic targets in cancer. Various strategies have been employed to evaluate the interference of tumor-promoting effects or the enhancement of tumor suppressive effects. The inhibition of the Eph-ephrin system

• In summary EP signaling modulates heteromeric kainate recept

  2019-07-19

  

  In summary, EP1 signaling modulates heteromeric kainate receptors at multiple steps, both sensitizing mice to kainate-evoked status epilepticus and, separately, exacerbating the downstream consequences of status epilepticus. These results, together with those of Serrano et al. (2011) and Jiang et a

• In patients with CTEPH ET levels are raised and

  2019-07-19

  

  In patients with CTEPH, ET-1 levels are raised and have been shown to fall after PEA surgery [24]. After an acute pulmonary embolism there is obstruction of the pulmonary Fmoc-Ser(tBu)-OH by acute thrombus and elevated levels of ET-1 [28], [30]. Elevated levels of ET-1 have also been observed in ai

• Covalent inhibitors are well suited for targeting the E enzy

  2019-07-19

  

  Covalent inhibitors are well suited for targeting the E1 PKA inhibitor fragment (6-22) amide is of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring co

• Epitope analyses of AT AA and ET AA indicate that

  2019-07-19

  

  Epitope analyses of AT1-AA and ET-AA indicate that the Toremifene of both autoantibodies are located at the second extracelluar loop of both receptors. The specific epitopes for both autoantibodies are similar to what was reported previously in a cohort of patients from Brazil [6] and for AT1-AA als

15911 records 986/1061 page Previous Next First page 上5页 986987988989990 下5页 Last page