• ABT-263 (Navitoclax): Probing Mitochondrial Apoptosis via...

  2025-09-22

  Explore how ABT-263 (Navitoclax), a potent Bcl-2 family inhibitor, is advancing mechanistic research into the mitochondrial apoptosis pathway and the newly characterized Pol II degradation-dependent apoptotic response (PDAR). This article provides rigorous insights for cancer biology and apoptosis assay applications.

• ABT-737: Deciphering Selective Apoptosis in Hematologic a...

  2025-09-19

  Explore the rigorous application of ABT-737, a potent BH3 mimetic and BCL-2 protein inhibitor, in dissecting apoptosis induction in cancer cells. This article delves into selective antitumor strategies, mechanistic insights, and advanced research design using ABT-737 across lymphoma, multiple myeloma, SCLC, and AML models.

• ABT-263 (Navitoclax): Illuminating Bcl-2 Signaling and Ap...

  2025-09-18

  Explore how ABT-263 (Navitoclax), a potent Bcl-2 family inhibitor, enables dissection of mitochondrial apoptosis pathways and caspase signaling in cancer biology. This article integrates evidence from recent cell death research and provides advanced guidance for experimental design.

• br Conclusion The HT receptor

  2025-03-03

  

  Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless EDTA-free protease inhibitor solution (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological

• Micro BCA protein measurement Additionally regulation of GPC

  2025-03-03

  

  Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut

• Dioscin Introduction hydroxytryptamine HT is found throughou

  2025-03-03

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary Dioscin (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current classificatio

• In order to investigate their effects in vitro

  2025-03-03

  

  In order to investigate their effects in vitro, therefore, we first used TE671 cells, which have provided a useful source of human AChR for in vitro and radioimmunoassay studies. We found no marked effect of either MuSK-MG or SNMG sera on AChR numbers or on AChR subunit expression. This appears to c

• Casein accounts for of the total protein

  2025-03-03

  

  Casein accounts for 80% of the total protein in bovine milk (Capriotti, Cavaliere, Piovesana, Samperi, & Laganà, 2016); hydrolysates or bioactive peptides derived from casein have been employed widely in food as a functional ingredient (Capriotti et al., 2016, Field et al., 2008). Many studies have

• It has been known that LOX

  2025-03-03

  

  It has been known that 5-LOX is the rate-limiting enzyme for the products of LTs, and LTs actively participate in the activation of neutrophils [10]. In our study, we determined whether 5-LOX was upregulated in pancreatic tissues during ANP. Moreover, we investigated whether the inhibition of expres

• Previously several genes such as cytokine Lyu

  2025-03-03

  

  Previously, several genes such as cytokine (Lyu and Park, 2007), cell motility-associated genes (Schotterl et al., 2017), transforming growth factor-β (TGF-β), TGF-β receptor II which is a cell surface receptor with serine/threonine kinase activity (Jiang et al., 2014, Schotterl et al., 2017), cell

• Fenofibric acid Skeletal pain associated with bone fracture

  2025-03-03

  

  Skeletal pain associated with bone fracture is another area of critical need for a novel pain medication. NSAIDs and opiates are the two major therapies currently used to manage bone fracture pain. However, both of these therapies lead to significant unwanted side effects. Using the osteotomy model

• Many ruthenium complexes were tested

  2025-03-01

  

  Many ruthenium complexes were tested as potential anticancer agents and two complexes, namely NAMI-A (trans-[imH] [RuCl4(dmso-S)(im)]; im, imidazole) and KP1019 (trans-[indH][RuCl4(ind)2]; ind, indazole) have successfully entered clinical trials [27], [28]. NAMI-A is selectively active against metas

• Although the LB domains of

  2025-03-01

  

  Although the LB2 domains of mGlu receptors have not been shown to form an extensive interface during activation, they do draw closer to each other, as demonstrated in crystal structures (Kunishima et al., 2000, Muto et al., 2007, Tsuchiya et al., 2002) and by FRET analysis (Doumazane et al., 2013, V

• Furthermore low affinity sites that

  2025-03-01

  

  Furthermore, low-affinity sites that share no structural homology with the aforementioned sites have been described in the transmembrane domain. It has been discovered that, in α1βγ2 receptors, potentiation of GABA-activated currents by high concentrations of diazepam is biphasic, with a high- and a

• br Experimental section br Acknowledgements br Introduction

  2025-03-01

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming WIN 18446 in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively correlated w

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